GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7045640 | 1 | rs7033675 | chr9:2969877 | KIAA0020 | chr9:2804155-2844130:- | -0.49 | -4.87 | 1.66E-6 | Systolic blood pressure in sickle cell anemia |
| BLCA | cis | rs881375 | 1 | rs7037140 | chr9:123656327 | LOC253039 | chr9:123605320-123616644:+ | -0.36 | -6.07 | 3.13E-9 | Rheumatoid arthritis |
| BLCA | cis | rs703842 | 1 | rs703842 | chr12:58162739 | FAM119B | chr12:58166383-58176323:+ | -0.27 | -4.32 | 1.96E-5 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs703842 | chr12:58162739 | TSFM | chr12:58176536-58191367:+ | 0.38 | 6.86 | 2.79E-11 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs703842 | chr12:58162739 | XRCC6BP1 | chr12:58335445-58351051:+ | 0.23 | 4.03 | 6.86E-5 | Multiple sclerosis |
| BLCA | cis | rs877636 | 1 | rs705696 | chr12:56480648 | RPS26 | chr12:56435686-56438005:+ | 0.45 | 7.32 | 1.46E-12 | Cognitive function |
| BLCA | cis | rs7061710 | 1 | rs7061710 | chr1:171080615 | FMO2 | chr1:171154388-171181822:+ | -0.24 | -4.69 | 3.89E-6 | Blood metabolite levels |
| BLCA | cis | rs7072216 | 1 | rs7072216 | chr10:100156853 | PYROXD2 | chr10:100143323-100174978:- | 0.29 | 6.67 | 8.78E-11 | Metabolite levels |
| BLCA | cis | rs12220238 | 1 | rs7073432 | chr10:75953350 | ADK | chr10:75910965-76469059:+ | 0.33 | 4.82 | 2.06E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs7073432 | chr10:75953350 | AP3M1 | chr10:75880016-75910826:- | 0.31 | 3.94 | 9.76E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs7076721 | chr10:75996682 | ADK | chr10:75910965-76469059:+ | 0.29 | 4.39 | 1.47E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs7081350 | chr10:75990328 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.55 | 7.23E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs7083534 | chr10:75955672 | ADK | chr10:75910965-76469059:+ | 0.31 | 4.71 | 3.41E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs7096553 | chr10:75957835 | ADK | chr10:75910965-76469059:+ | 0.31 | 4.73 | 3.2E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs7927771 | 1 | rs7105282 | chr11:47805614 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.58 | 4.62E-8 | Subjective well-being |